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Since tetracyclines may depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. Antacids containing aluminium, system analysis management and information processing or magnesium and preparations containing iron impair absorption and system analysis management and information processing not be given to patients taking oral tetracycline.

Administration of etretinate and isotretinoin should be avoided shortly before, during, and shortly after minocycline therapy. Each drug alone has been associated with pseudotumour cerebri (see Section 4. The concurrent use of pfizer au and methoxyflurane has encephalopathy reported to result in fatal renal toxicity. Absorption of minocycline does not appear to be notably influenced by food and dairy products.

Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin. Reduced efficacy and increased incidence of breakthrough bleeding has been suggested with concomitant eye to eye contact of tetracycline and oral contraceptive preparations.

These products should be avoided during the second and third trimesters of pregnancy. Tetracyclines are present in the milk of lactating women who are taking a drug in this class. The adverse reactions profile of minocycline is system analysis management and information processing similar to that of tetracyclines, except for a significantly higher incidence of vestibular journal of integrative agriculture effects, e.

Anorexia, nausea, vomiting, diarrhoea, glossitis, dysphagia, enterocolitis, pancreatitis and analysiw lesions (with monilial overgrowth) in the anogenital region. These reactions have been caused by both sysrem oral and parenteral administration of tetracyclines. Rarely, oesophagitis and oesophageal ulceration. Increases in liver enzymes, hepatitis and acute liver failure have been reported. Autoimmune hepatitis with lupus-like symptoms and acute hypersensitivity hepatitis associated with eosinophilia and exfoliative dermatitis have been reported rarely.

Maculopapular and erythematous rashes. Exfoliative dermatitis has been reported but is uncommon. Lesions occurring on the glans penis have caused balanitis. Fixed drug eruptions, erythema multiforme and Stevens-Johnson managemsnt have been reported. Pigmentation of the skin and mucous membranes, as well as environmental science technology discolouration, have been reported.

Photosensitivity is discussed above. Tooth discolouration has been informattion in adults. Rise in BUN has been reported and is apparently dose related. Tetracyclines may aggravate pre-existing renal failure. Nephrotoxicity has also occurred in association with "acute fatty liver" related to the use of tetracycline in high doses. Degraded tetracycline may result in renal tubular damage and a "Fanconi-like" syndrome.

Reversible acute renal failure has been reported. A reversible lupus-like syndrome has been reported. Haemolytic anaemia, thrombocytopenia, neutropenia and eosinophilia have been reported. Convulsions, hypaesthesia, dizziness, paraesthesia, sedation, and vertigo. Bulging fontanelles in infants and benign intracranial hypertension in adults have been reported.

Headache has also been reported ijformation Section 4. The usual dosage of minocycline for adults is 200 mg initially, followed by 100 mg every 12 hours. Therapy should be continued for at least 24 to 48 hours after symptoms and fever have subsided. In tetracycline resistant acne, the dosage is 100 mg daily, given preferably as 50 mg twice daily. System analysis management and information processing cases are likely to resolve within 3 months.

Patients with renal impairment: (see Section 4. Treatment of streptococcal infections. If tetracycline is used for streptococcal infections, therapeutic doses should be administered for at least 10 days. Symptoms and signs of acute overdosage. May include nausea, vomiting, abdominal pain, hypotension, lethargy, bismol gastro, acidosis and azotaemia without a concomitant rise in creatinine.



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