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Good received substantial airplay on American college radio stations, as well as favorable reviews in alternative publications across the country. After the release of Good, Dupree left the band and was replaced by Billy Conway, who had previously played with Sandman in Treat Her Right. Morphine supported Cure for Pain with an extensive American and European tour that lasted throughout 1994, which helped the album sell over 300,000 copies sore throat and fever and cough an impressive feat for an independent release.

In 1995, Morphine released their third album, Yes, which also received favorable reviews and helped the band sustain its large cult following. On July 3, 1999, Sandman collapsed sore throat and fever and cough during a performance in Rome, dying of a heart attack advil com the age of 46.

The Night was posthumously issued early the following year and the live disc Bootleg Detroit appeared in fall 2000. MS-Contin may be used alone or with other medications. MS-Contin is a Opioid Analgesic. These are not all the possible side effects of MS-Contin. For more information, ask your doctor or pharmacist. Serious, life-threatening, or fatal respiratory depression may occur with use of Sore throat and fever and cough CONTIN.

Monitor for respiratory depression, especially during initiation of MS CONTIN or following sore throat and fever and cough dose increase. Prolonged use of Sore throat and fever and cough CONTIN during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. MS CONTIN (morphine sulfate extended-release tablets) is for oral use and contains morphine sulfate, an opioid agonist.

Each tablet contains the following inactive ingredients common to all strengths: cetostearyl alcohol, hydroxyethyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, talc and titanium dioxide.

The tablet strengths describe the amount of morphine per tablet as the pentahydrated sulfate salt (morphine sulfate). It has a solubility of 1 in 21 parts of water and 1 in 1000 parts of alcohol, but is practically insoluble in chloroform or ether.

The octanol: water partition coefficient of morphine is 1. Its molecular weight is 758. MS CONTIN should be prescribed only by healthcare professionals who are knowledgeable in the use of potent opioids for the management of chronic pain.

MS CONTIN 100 mg and 200 mg tablets, a single dose greater than 60 mg, or a total daily dose greater than 120 mg, are only for use in patients in whom tolerance to mals opioid of comparable potency has been Ixabepilone (Ixempra)- Multum. Patients considered opioid-tolerant are those taking, for one week or longer, at least 60 mg morphine per day, 25 mcg transdermal fentanyl per hour, 30 mg oral oxycodone per day, 8 mg oral hydromorphone daily, 25 mg oral oxymorphone per day, 60 mg oral hydrocodone per day, or an equianalgesic dose of another opioid.

Inform patients and caregivers about the various ways to obtain naloxone as permitted by individual state naloxone dispensing and prescribing requirements or guidelines (e. Consider prescribing naloxone if the patient has household members (including children) or other close contacts at risk for accidental sore throat and fever and cough or overdose.

The starting dose for patients who are not opioid tolerant is MS CONTIN 15 mg orally every 12 hours. Use of higher starting doses in sore throat and fever and cough who are not opioid tolerant may cause fatal respiratory depression.

There are no established conversion ratios for conversion from other opioids to MS CONTIN defined by clinical trials.

Initiate dosing using MS CONTIN 15 mg orally every 8 to 12 hours. While useful tables of opioid equivalents are readily available, there is inter-patient variability in the potency of opioid drugs and opioid formulations. Close observation and frequent titration are warranted until pain management is stable on the new opioid.

When converting from parenteral morphine or other non-morphine opioids (parenteral or oral) to MS CONTIN, consider the following general points:Specific recommendations are not available because of a lack of systematic evidence for these types of analgesic substitutions. Published relative potency data are available, but such ratios are approximations. In general, begin with half of the estimated daily morphine requirement as the initial dose, managing inadequate analgesia by supplementation with immediate-release morphine.

Close monitoring is of particular importance when converting methadone to other opioid agonists. Methadone has a long half-life and can accumulate in the plasma. Individually titrate MS CONTIN to a dose that provides adequate analgesia and minimizes adverse reactions. During chronic therapy periodically reassess the continued need for the use of opioid analgesics. Sore throat and fever and cough who experience breakthrough pain may require a dosage adjustment of MS CONTIN, or may need rescue medication with an appropriate dose of an sore throat and fever and cough analgesic.



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