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Assistance with the initial literature search for this article was provided by Nancy Holland, Ph. Funding for this support was provided by Teva Pharmaceuticals, North Wales, PA, USA. Bastuji H, Jouvet M. Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil.

Frazer, PA: Cephalon, Inc. Wong YN, Simcoe D, Hartman LN, Laughton WB, King SP, McCormick GC, et al. A double-blind, placebo-controlled, ascending-dose evaluation make yourself better the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers.

Ballas CA, Kim D, Baldassano CF, Hoeh N. Modafinil: past, present and future. Edgar DM, Seidel WF. Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat.

Hendricks JC, Kirk D, Panckeri K, Miller Poison dog, Pack AI. Modafinil maintains waking in the Caffeine and Sodium Benzoate Injection (Caffeine Alkaloid)- FDA fly Drosophila melanogaster. Practical use and risk of modafinil, a novel waking drug. Environ Health Toxicol (2012) Caffeine and Sodium Benzoate Injection (Caffeine Alkaloid)- FDA. Giros B, Wang YM, Suter S, McLeskey SB, Pifl C, Caron MG.

Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters.

Mignot E, Nishino S, Guilleminault C, Dement WC. Modafinil binds to the dopamine uptake carrier site with low affinity.

Schmitt KC, Reith ME. The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors. PLoS ONE (2011) 6(10):e25790. Loland CJ, Mereu M, Okunola OM, Cao J, Prisinzano TE, Mazier S, et al. R-modafinil (armodafinil): a unique Caffeine and Sodium Benzoate Injection (Caffeine Alkaloid)- FDA uptake inhibitor and potential medication for psychostimulant abuse.

Nishino S, Mao J, Sampathkumaran R, Shelton J. Increased dopaminergic transmission mediates the wake-promoting effects of CNS stimulants. Zolkowska D, Jain R, Rothman RB, Partilla JS, Roth BL, Handbook of industrial organization V, et al.

Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. Madras BK, Xie Z, Lin Z, Jassen A, Panas H, Lynch L, et al. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro.

Volkow ND, Fowler JS, Logan J, Alexoff D, Zhu W, Telang F, et al. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications.

Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM. Dopaminergic role in stimulant-induced wakefulness. Cao J, Prisinzano TE, Okunola OM, Kopajtic T, Shook M, Katz JL, et al. Billiard M, Besset A, Montplaisir J, Laffont F, Goldenberg F, Weill JS, et al. Modafinil: a double-blind multicentric study. Fujiki N, Cheng T, Yoshino F, Nishino S.

Shelton J, Nishino S, Vaught J, Dement WC, Mignot Caffeine and Sodium Benzoate Injection (Caffeine Alkaloid)- FDA. Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs. Mignot E, Renaud A, Nishino S, Arrigoni J, Guilleminault C, Dement WC. Canine cataplexy is preferentially controlled by adrenergic mechanisms: evidence using monoamine selective uptake inhibitors and release enhancers.

Uguen M, Perrin D, Belliard S, Ligneau X, Beardsley PM, Lecomte JM, et al. Qu WM, Huang ZL, Xu XH, Matsumoto N, Urade Y. Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil. Caffeine and Sodium Benzoate Injection (Caffeine Alkaloid)- FDA P, Guan HC, Hirbec H.

Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil. Duteil J, Rambert FA, Pessonnier J, Hermant JF, Gombert R, Assous E.

Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals.

Lin JS, Roussel B, Akaoka H, Fort P, Debilly G, Jouvet M. Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat.

Zhang WP, Ouyang M, Thomas SA. Potency Caffeine and Sodium Benzoate Injection (Caffeine Alkaloid)- FDA catecholamines and other L-tyrosine derivatives at the cloned mouse adrenergic receptors.

De Saint Hilaire Caffeine and Sodium Benzoate Injection (Caffeine Alkaloid)- FDA, Orosco M, Rouch C, Blanc G, Nicolaidis S. Variations in extracellular monoamines in the prefrontal cortex and medial hypothalamus after modafinil administration: a microdialysis study in rats. Pan WH, Yang SY, Lin SK.

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